Conotoxin |129129-65-3

Iiconotoxins liqela elahlukileyo leetyhefu ezincinci zepeptide eziveliswa ziicone snails (igenus Conus).Ezi nkumba zaselwandle zifumaneka kulwandle olushushu kunye nolwaselwandle kwaye zaziwa ngendlela ekhethekileyo yokuzingela.Inkumba yecone isebenzisa ubuthi ukunqanda ixhoba labo, elibandakanya ikakhulu ezinye izinto eziphila elwandle njengentlanzi kunye neentshulube.

Iiconotoxins zifumaneka kwityhefu yeenkumba zecone kwaye zisebenza ngeenjongo ezahlukeneyo, ezinjengokoyisa ixhoba kunye nokukhusela kumarhamncwa.I-peptides kwi-conotoxins inoluhlu olubanzi lwemisebenzi ye-pharmacological kwaye inokusebenzisana nama-receptors athile kunye neziteshi ze-ion kwinkqubo ye-nervous.Ngenxa yokuchaneka kwazo okuphezulu kwiithagethi ezithile, ii-conotoxins zitsale ingqalelo kubaphandi ngokusetyenziswa kwazo okunokwenzeka kumayeza kunye nophuhliso lwamachiza.

I-Conotoxins ihlelwe kwiintsapho ezininzi ngokusekelwe kwisakhiwo sabo kunye ne-receptors ekujoliswe kuyo abasebenzisana nayo.Ezinye iintsapho ziquka:

I-A-conotoxins: Ujoliso lwe-nicotinic acetylcholine receptors.

I-M-conotoxins: I-Block voltage-gated sodium channels.

I-O-conotoxins: Sebenzisana ne-voltage-gated calcium channels.

I-T-conotoxins: Iitshaneli ze-potassium ezijoliswe kumbane-gated.

Ezi tyhefu ziye zabonisa isithembiso ekuphuhliseni amachiza amatsha okulawula intlungu, ukuphazamiseka kwe-neurological, kunye nezinye iimeko zonyango.Izazinzulu zinomdla ngakumbi kwisakhono sazo sokukhetha ukumodareyitha ii-receptors ezithile, zizenze zibe nexabiso kuyilo lwamachiza ekujoliswe kuwo nasebenzayo.

Umqulu:25KG/BAG okanye njengoko ucela.

Ugcino:Gcina kwindawo engenamoya, kwindawo eyomileyo.

IsigqebaUmgangatho:Umgangatho wamazwe ngamazwe.