Uridine | 58-96-8

I-Uridine yi-nucleoside ye-pyrimidine esebenza njengesiseko sokwakha i-RNA (i-ribonucleic acid), enye yeentlobo ezimbini eziphambili ze-nucleic acids eziyimfuneko ekugcinweni nasekuhanjisweni kolwazi lofuzo kwiiseli.

Isakhiwo seMichiza: I-Uridine iqulethe i-pyrimidine base uracil eqhotyoshelwe kwi-carbon-carbon sugar ribose nge-beta-N1-glycosidic bond.

Indima yebhayoloji:

I-RNA Building Block: I-Uridine yinxalenye ebalulekileyo ye-RNA, apho yenza umqolo wee-molecule ze-RNA kunye nezinye i-nucleosides ezifana ne-adenosine, i-guanosine kunye ne-cytidine.

I-Messenger RNA (mRNA): Kwi-mRNA, iintsalela ze-uridine zidibanisa ulwazi lwezofuzo ngexesha lokubhalwa, liphethe imiyalelo esuka kwi-DNA ukuya kumatshini we-protein synthesis kwiseli.

Dlulisa i-RNA (tRNA): I-Uridine ikhona kwakhona i-molecule ye-intRNA, apho ithatha inxaxheba kwinkqubo yokuguqulela ngokuqaphela ii-codons ezithile kunye nokuhambisa i-amino acids ehambelana ne-ribosome.

I-Metabolism: I-Uridine inokwenziwa nge-novo ngaphakathi kweeseli okanye ifunyenwe kwimithombo yokutya. Iveliswa ngokuguqulwa kwe-enzymatic ye-orotidine monophosphate (OMP) okanye i-uridine monophosphate (UMP) kwindlela ye-pyrimidine biosynthesis.

Ukubaluleka kokuPhila:

I-Neurotransmitter Precursor: I-Uridine idlala indima ekusebenzeni kwengqondo kunye nophuhliso. Yisandulela sokwenziwa kwe-phospholipids yobuchopho, kuquka i-phosphatidylcholine, eyimfuneko kwi-neuronal membrane integrity kunye ne-neurotransmitter signaling.

I-Neuroprotective Effects: I-Uridine ifundwe ngeempawu zayo ezinokuthi zikhuseleke kunye nokukwazi kwayo ukuphucula umsebenzi we-synaptic kunye ne-neuronal plasticity.

Amandla oNyango:

I-Uridine kunye ne-derivatives yayo iphandiwe malunga nezicelo zonyango ezinokubakho kwiingxaki ze-neurological, kubandakanywa nesifo se-Alzheimer kunye nokuphazamiseka kwemizwelo.

Ukuxhaswa kwe-Uridine kuhlolwe njengesicwangciso sokuxhasa umsebenzi wokuqonda kunye nokunciphisa iimpawu ezinxulumene nezifo ze-neurodeergenerative.

Imithombo yokutya: I-Uridine ifumaneka ngokwemvelo kwizinto ezahlukeneyo zokutya, kuquka inyama, intlanzi, imifuno, kunye neemveliso zobisi.