Tacrolimus | 104987-11-3

I-Tacrolimus, eyaziwa ngegama layo lezorhwebo iPrograf phakathi kwabanye, lichiza elinamandla le-immunosuppressive elisetyenziswa ngokuyintloko kufakelo lwamalungu ukuthintela ukwaliwa.

I-Mechanism of Action: I-Tacrolimus isebenza ngokuvimbela i-calcineurin, i-protein phosphatase edlala indima ebalulekileyo ekusebenzeni kwe-T-lymphocytes, iiseli zokuzivikela ezibandakanyekayo ekugayweni kwe-graft. Ngokuthintela i-calcineurin, i-tacrolimus ivimba ukuveliswa kwe-cytokines e-pro-inflammatory kunye nokuthintela ukusebenza kweeseli ze-T, ngaloo ndlela icinezela impendulo yokuzivikela kwi-organ etshintshwe.

Izibonakaliso: I-Tacrolimus iboniswa kwi-prophylaxis yokulahlwa kwelungu kwizigulane ezifumana i-allogeneic isibindi, izintso, okanye ukutshintshwa kwentliziyo. Ihlala isetyenziselwa ukudibanisa nezinye i-immunosuppressive agents ezifana ne-corticosteroids kunye ne-mycophenolate mofetil.

Ulawulo: I-Tacrolimus ilawulwa ngomlomo ngendlela yee-capsules okanye isisombululo somlomo. Inokuthi ifakwe emithanjeni kwiimeko ezithile zeklinikhi, njengakwithuba elikhawulezayo lasemva koqhaqho.

Ukubeka iliso: Ngenxa yesalathiso esincinci sonyango kunye nokwahluka kokufunxa, i-tacrolimus ifuna ukujonga ngononophelo amanqanaba egazi ukuqinisekisa ukusebenza ngempumelelo konyango ngelixa unciphisa umngcipheko wetyhefu. Ukujongwa kweziyobisi zonyango kubandakanya ukulinganisa rhoqo amanqanaba egazi e-tacrolimus kunye nohlengahlengiso lwedosi esekelwe kula manqanaba.

Iziphumo ezibi: Iziphumo eziqhelekileyo ze-tacrolimus ziquka i-nephrotoxicity, i-neurotoxicity, i-hypertension, i-hyperglycemia, ukuphazamiseka kwesisu, kunye nokunyuka kokungenwa kwezifo. Ukusetyenziswa kwexesha elide kwe-tacrolimus kunokonyusa umngcipheko wokuphuhlisa izifo ezithile, ngakumbi umhlaza wolusu kunye ne-lymphoma.

Ukusebenzisana kweziyobisi: I-Tacrolimus i-metabolized ngokuyinhloko yinkqubo ye-enzyme ye-cytochrome P450, ngakumbi i-CYP3A4 kunye ne-CYP3A5. Ke ngoko, iziyobisi ezikhuthaza okanye ezithintela ezi enzymes zinokuchaphazela amanqanaba e-tacrolimus emzimbeni, ezinokukhokelela ekusileleni konyango okanye ubuthi.

Ukuqwalaselwa okuKhethekileyo: I-Tacrolimus dosing ifuna umntu ngamnye ngokusekelwe kwizinto ezifana nobudala besigulane, ubunzima bomzimba, umsebenzi wezintso, amayeza adibeneyo, kunye nobukho be-co-morbidities. Ukubeka iliso olusondeleyo kunye nokulandelela rhoqo kunye nababoneleli bezempilo kubalulekile ekuphuculeni unyango kunye nokunciphisa iziphumo ezibi.