Huperzine A ｜120786-18-7

I-Huperzine A yi-cognitive enhancer evimbela i-enzymes ehlisa i-neurotransmitter acetylcholine yokufunda. Kukwiklasi ye-cholinergic yeemolekyuli ezinokunceda ukulwa nokuncipha kwengqondo kubantu abadala.

I-Huperzine A yi-compound ekhutshwe kwintsapho ye-huperzine. Ibizwa ngokuba yi-acetylcholinesterase inhibitor, oku kuthetha ukuba ikhusela i-enzyme ekuphuleni i-acetylcholine, ekhokelela ekwandeni kwe-acetylcholine.

I-acetylcholine ibizwa ngokuba yi-neurotransmitter yokufunda kwaye ikwabandakanyeka ekunqanyulweni kwemisipha.

I-Huperzine A ibonakala iyikhompawundi ekhuselekileyo. Ubuthi kunye nezifundo zabantu ezivela kwizifundo zezilwanyana ziye zabonisa ukuba akukho ziphumo bezingalindelekanga kwiidosi ezongezelelweyo eziqhelekileyo. I-Huperzine A ikwasetyenziswa kulingo lokuqala ukuthintela isifo sika-Alzheimer.

I-Huperzine A ivela kulwelo lwe-cerebrospinal kwaye iwela lula umqobo wegazi-ingqondo.

I-Huperzine A yaziwa kakhulu njenge-acetylcholinesterase inhibitor. Ngokukodwa, inqanda i-G4 subtype ye-acetylcholinesterase, eqhelekileyo kwiingqondo ze-mammalian. Isebenza ngakumbi okanye ngokulinganayo ngokuchasene nezinye i-acetylcholinesterase inhibitors, ezifana ne-tacillin okanye i-rivastatin. Njenge-inhibitor, inobudlelwane obuphezulu be-acetylcholinesterase. Kwangaxeshanye, ine-dissociation ecothayo engaguqukiyo, eyenza isiqingatha sobomi bayo bube bubude kakhulu.

Ukongeza ekuvimbeleni i-acetylcholinesterase, inokubonwa njenge-neuroprotective ngokumelene ne-glutamate, i-beta amyloid pigmentation, kunye ne-H2O2-induced toxicity.

I-Huperzine A inokukhuthaza ukwanda kweeseli ze-hippocampal neural stem (NSCs). Kubonakala ngathi ikhuthaza ukukhula kwemithambo-luvo kwiidosi ezinxulumene ne-biorelated.