Fludarabine | 21679-14-1
Ingcaciso yeMveliso
I-Fludarabine liyeza le-chemotherapy elisetyenziswa ikakhulu kunyango lweentlobo ezithile zomhlaza, ngakumbi i-hematological malignancies. Nantsi isishwankathelo:
I-Mechanism of Action: I-Fludarabine yi-analog ye-nucleoside ephazamisa ukuhlanganiswa kwe-DNA kunye ne-RNA. Ivimbela i-DNA polymerase, i-DNA primase, kunye ne-DNA ligase enzymes, ekhokelela ekuqhekekeni kwe-DNA strand kunye nokuvinjelwa kweendlela zokulungisa i-DNA. Oku kuphazamiseka kwe-DNA synthesis ekugqibeleni kubangela i-apoptosis (ukufa kweseli ecwangcisiweyo) kwiiseli ezahlula ngokukhawuleza, kubandakanya iiseli zomhlaza.
Izibonakaliso: I-Fludarabine isetyenziswa ngokuqhelekileyo kunyango lwe-lymphocytic leukemia (CLL), kunye nezinye izifo ze-hematological ezifana ne-indolent non-Hodgkin lymphoma kunye ne-mantle cell lymphoma. Isenokusetyenziswa kwiimeko ezithile ze-acute myeloid leukemia (AML).
Ulawulo: I-Fludarabine ilawulwa ngokuqhelekileyo nge-intravenously (IV) kwimeko yeklinikhi, nangona inokuthi inikwe ngomlomo kwezinye iimeko. Idosi kunye neshedyuli yolawulo ixhomekeke kumhlaza othile onyangwayo, kunye nempilo yonke yesigulane kunye nempendulo kunyango.
Iziphumo ezibi: Imiphumo eqhelekileyo ye-fludarabine ibandakanya ukunyanzeliswa komnkantsha wethambo (okukhokelela kwi-neutropenia, i-anemia, kunye ne-thrombocytopenia), isicaphucaphu, ukuhlanza, isifo sohudo, umkhuhlane, ukukhathala, kunye nokunyuka kwezifo. Inokubangela iziphumo ezibi kakhulu ezinje nge-neurotoxicity, i-hepatotoxicity, kunye ne-pulmonary toxicity kwezinye iimeko.
Izilumkiso: I-Fludarabine ichasene nezigulane ezinoxinzelelo olunzima lwamathambo okanye ukungasebenzi kakuhle kwezintso. Kufuneka isetyenziswe ngononophelo kwizigulane ezinesifo sesibindi esele sikhona okanye isifo sezintso, kunye nabasetyhini abakhulelweyo okanye abancancisayo ngenxa yobungozi obunokubakho kumntwana okanye usana.
Ukusebenzisana kweziyobisi: I-Fludarabine inokusebenzisana namanye amayeza, ngokukodwa ezo zichaphazela umsebenzi we-bone marrow okanye umsebenzi wezintso. Kubalulekile ukuba ababoneleli bezempilo baphonononge uluhlu lwamayeza esigulana ngononophelo kwaye babeke iliso kunxibelelwano olunokwenzeka lwamachiza.
Ukubeka iliso: Ukubeka iliso rhoqo ukubala kwegazi kunye nokusebenza kwezintso kubalulekile ngexesha lonyango nge-fludarabine ukuvavanya iimpawu zokunciphisa umongo okanye ezinye iziphumo ezibi. Uhlengahlengiso lwethamo lunokuba yimfuneko ngokusekelwe kwezi parameters zokubeka iliso.
Iphakheji
25KG/BAG okanye njengoko ucela.
Ugcino
Gcina kwindawo engenamoya, kwindawo eyomileyo.
Umgangatho woLawulo
Umgangatho wamazwe ngamazwe.
