Adenosine | 58-61-7

I-Adenosine, i-nucleoside eyenziwe nge-adenine kunye ne-ribose, inezicelo ezininzi ezibalulekileyo kumayeza kunye ne-physiology ngenxa yeziphumo zayo zomzimba kwiinkqubo ezahlukeneyo emzimbeni.

Amayeza entliziyo:

Isixhobo sokuxilonga: I-Adenosine isetyenziswe njenge-agent ye-pharmacological stress ngexesha lovavanyo loxinzelelo lwentliziyo, njenge-imaging ye-myocardial perfusion. Inceda ukuvavanya isifo se-coronary artery ngokufaka i-coronary vasodilation, ukulinganisa imiphumo yokuzivocavoca umzimba.

Unyango lwe-Supraventricular Tachycardia (SVT): I-Adenosine yonyango lokuqala lokuphelisa iziqendu ze-SVT. Isebenza ngokucotha ukuqhuba ngokusebenzisa i-atrioventricular node, ukuphazamisa iindlela zokubuyela kwakhona ezijongene ne-SVT.

I-Neurology:

Ulawulo lokuxhuzula: I-Adenosine yi-anticonvulsant engapheliyo kwingqondo. Ukumodareyitha i-adenosine receptors kunokuba neziphumo zokulwa nokuxhuzula, kwaye ii-adenosine-release agents ziphandwa njengonyango olunokubakho kwisifo sokuxhuzula.

I-Neuroprotection: I-Adenosine receptors idlala indima ekukhuseleni i-neurons kwingozi ye-ischemic kunye noxinzelelo lwe-oxidative. Uphando luphonononga amandla e-adenosine njenge-agent ye-neuroprotective kwi-stroke kunye nezifo ze-neurodeergenerative ezifana ne-Parkinson kunye ne-Alzheimer's.

Iyeza lokuphefumla:

I-Bronchodilation: I-Adenosine isebenza njenge-bronchodilator kwaye isetyenziselwa uvavanyo lwe-bronchoprovocation ukufumanisa isifo sombefu. Ibangela i-bronchoconstriction kubantu abane-asthma, inceda ukuchonga i-hyperreactivity yomoya.

Iinkcazelo ngeempawu ze-Antiarrhythmic:

I-Adenosine inokucinezela iintlobo ezithile ze-arrhythmias ngokumodareyitha umsebenzi wombane entliziyweni, ngakumbi kwi-atria kunye ne-atrioventricular node. Isiqingatha sayo sobomi obufutshane sinciphisa iziphumo zenkqubo.

Isixhobo soPhando:

I-Adenosine kunye ne-analogs yayo isetyenziswa ngokubanzi kuphando lokufunda indima ye-adenosine receptors kwiinkqubo ezahlukeneyo ze-physiological and pathological. Banceda ukucacisa imisebenzi ye-adenosine kwi-neurotransmission, impendulo yomzimba, ukuvuvukala, kunye nokulawulwa kwentliziyo.

Usetyenziso olunokubakho loNyango:

Iziyobisi ezisekelwe kwi-Adenosine ziphandwa kwizicelo ezinokubakho zonyango kwiimeko ezinjengomhlaza, ukwenzakala kwe-ischemic, ulawulo lweentlungu, kunye nokuphazamiseka kokudumba. I-Adenosine receptor agonists kunye nabachasi baphakathi kweekhompawundi eziphantsi kophando.